The Colorectal Surgery Institute performs evaluation procedures

and treats a comprehensive list of conditions, including inflammatory bowel disease, function disorders and non-cancerous anorectal disease.

Lynch syndrome


Lynch syndrome (HNPCC or hereditary nonpolyposis colorectal cancer) is an inherited genetic condition that has a high risk of colon cancer as well as other cancers including endometrial cancer ovarian and stomach cancer. If certain cancer-fighting genes are broken or mutated, you may be at higher risk for these conditions.

Testing for lynch syndrome can be done through a saliva sample. If the conclusions of the test show a mutation in the MLH1, MLH2, MSH6, EPCAM or PMS2, you are considered to have Lynch syndrome. Individuals with Lynch syndrome have an up to 82% change of getting colorectal cancer and women have an up to 71% of uterine cancer. These risks can be reduced by having more frequent colonoscopies, ultrasounds, and even surgery if necessary.

If you have Lynch syndrome, sharing the information with your family is very important because direct relatives have a 50% chance of having the same mutated gene. Hereditary cancer testing is the only way to know who has the broken gene in the family.

Red Flags

Individuals with the following:

  • Colorectal or endometrial cancer before age 50
  • MSI High histology before age 60
  • Abnormal MSI/IHC tumor test results (colorectal/endometiral)
  • Two or more Lynch syndrome cancers at any age
  • Lynch syndrome cancer with one or more relatives with a Lynch syndrome cancer*
  • 10 or more cumulative colorectal adenomas at any age

An individuals with any of the following family histories:

  • A first- or second-degree relative with colorectal or endometrial cancer before age 50
  • Two or more relatives with a Lynch syndrome cancer, one before the age of 50
  • Three or more relatives with a Lynch syndrome cancer at any age
  • A previously identified Lynch syndrome, MAP, AFAP, or FAP syndrome mutation in the family
  • One of more relatives with 10 or more cumulative colorectal polyps (adenomas) at any age



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